Hepatoprotective activity of Andrographis paniculata (Kalmegh) & Swertia chirayita (Chirata) in Ethanol induced Hepatotoxicity in Albino Wistar Rats with respect to Standard medicine: Metadoxine
Introduction: Andrographis paniculata is a well known medicinal plant of ayurveda with various pharmacological as well as medicinal properties & Swertia chirayita is used in Indian Ayurvedic herbal system to cure fever as in Laghu Sudarshan churna, maha sudarshan churana in Tibetan folk medicine. It is also one of the most widely used medicinal plants of Sikkim & other parts of Himalaya
Aim & Objective: 1. To evaluate the potential hepatoprotectvie effect of S.chirayita & A.paniculata with respect to standard medicine: Metadoxine, in ethanol induced hepatotoxicity in wistar albino rats.
2. To evaluate the efficacy of A.Paniculata, S.Chirayata and Metadoxine in ethanol induced fatty liver in wistar albino rat.
Material & Methods: The hepatoprotective activity of methanolic extracts of A.paniculata (10mg/kg) & S.chirayita (10mg/kg) were evaluated against ethanol (2ml/kg) induced hepatotoxicity with respect to standard medicine : Metadoxine (500mg – 1 gm/kg/day), at specific time interval is to be carried out (n=6) in wistar albino rat in 5 groups.
Result: The result of the study is to evaluated by the crude extracts of A.paniculata & S.chirayita at doses of 10mg/kg in both, in comparison with standard medicine : Metadoxine & in combination of both extracts exhibited a significant protective effect in liver morphology of Ethanol induced hepatotoxicity in albino wistar rats.
Laboratory tests are to be carried out are SGPT, SGOT, ALP, TP, Total Bilibrubin and lipid profile of liver of albino rat to check the status of fatty liver.
Discussion: Presence of active compound, diterpene lactone, Kalmeghin, andrographolide in A.Paniculata and maniferin,amarogentin & swertimarin in S.chiarayata which have contributed to the hepatoprotective activity in comparison with Metadoxine. Various study says that the Metadoxine is having potential effect on ethanol intoxication, ethanol induced hepatotoxicity and ethanol induced fatty liver.
Conclusion: The present study indicates that A.paniculata & S.chirayita with respect to the standard medicine Metadoxine posses hepatoprotective effect which could compromise the medicinal use of these plants in folk medicine.